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OCR: emia may Anti-insulin receptor antibody hypogly ly of be the presenting feature of a wide varie mas. In d against autoimmune diseases, as well of lymph this condition, antibodies that are direct on and insulin receptors may mimic insulin ac se cause hypoglycaemia, or block it and cat in and intractable hyperglycaemia. Plasma insu when C-peptide levels may be high to very hig excessive blood glucose levels are elevated due to stimulation of the B cells, but are genere . The appropriately low during hypoglycaemi stimulatory antibodies may themselves the insulin first-generation antibodies (Ab1) against insulin receptor (Fig. 20.27) or antibodies agains antibodies (that is, anti-idiotypes: Ab2).